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Asian J Beauty Cosmetol > Accepted Articles

doi: https://doi.org/10.20402/ajbc.2017.0140    [Accepted]
New Development of Natural Depigmentation Agent from Anemarrhena asphodeloides Root Extracts by Inhibition of Melanin Biosynthesis
Soo-Kyung Seo1, Seong-Jeong Han1, Chang-Sub Ku1, Dae-Hyun Kim1, Ja-Hyun Ryu2, Ji-Hwoon Baek2, Jae-Sook Koh2, Dong-Il Jang1
1Cosmeceutical Science Institute, COTDE Inc., Cheonan-si, Chungcheongnam-do, Korea
2Dermapro Skin Research Center, DERMAPRO Ltd., Seoul, Korea
Corresponding author:  Ji-Hwoon Baek ,Tel: +82 41 556 1364, Fax: +82 41 587 1376, Email: daniel@cotde.co.kr
Received: April 14, 2017;  Accepted: November 13, 2017.  Published online: February 13, 2018.
ABSTRACT
Purpose:
This study aimed to confirm the depigmentation effects from Anemarrhena asphodeloides root extracts (AARE).
Method:
We assessed tyrosinase inhibition activity of AARE and investigated the biosynthesis of melanin in B16F10 melanoma cells and subjected to clinical trials with AARE creams.
Results:
Tyrosinase activity and melanin biosynthesis induced by α-melanocyte stimulating hormone (α-MSH) were inhibited by AARE in a concentration-dependent manner. In particular, at 25 μg/mL concentration, melanin biosynthesis was more effectively inhibited by AARE (28.4%) than arbutin (24.7%; a well-known melanin synthesis inhibitor). In clinical trials, we investigated the changes in human skin brightness values over eight weeks using a cream formulation that contained 2% AARE after inducing pigmentation via ultraviolet irradiation. We showed that the hyperpigmentation degree, melanin index, and skin brightness were significantly improved.
Conclusion:
AARE is expected to become widely available as a functional cosmetic material for skin whitening.
Key words: Anemarrhena asphodeloides, Tyrosinase, Natural depigmentation agent, Skin brightness, Melanin
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