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Asian J Beauty Cosmetol > Accepted Articles

doi: https://doi.org/10.20402/ajbc.2017.0140    [Accepted]
New Development of Natural Depigmentation Agent from Anemarrhena asphodeloides Root Extracts by Inhibition of Melanin Biosynthesis
Soo-Kyung Seo1, Seong-Jeong Han1, Chang-Sub Ku1, Dae-Hyun Kim1, Ja-Hyun Ryu2, Ji-Hwoon Baek2, Jae-Sook Koh2, Dong-Il Jang1
1Cosmeceutical Science Institute, COTDE Inc., Cheonan-si, Chungcheongnam-do, Korea
2Dermapro Skin Research Center, DERMAPRO Ltd., Seoul, Korea
Corresponding author:  Ji-Hwoon Baek ,Tel: +82 41 556 1364, Fax: +82 41 587 1376, Email: daniel@cotde.co.kr
Received: April 14, 2017;  Accepted: November 13, 2017.  Published online: February 13, 2018.
This study aimed to confirm the depigmentation effects from Anemarrhena asphodeloides root extracts (AARE).
We assessed tyrosinase inhibition activity of AARE and investigated the biosynthesis of melanin in B16F10 melanoma cells and subjected to clinical trials with AARE creams.
Tyrosinase activity and melanin biosynthesis induced by α-melanocyte stimulating hormone (α-MSH) were inhibited by AARE in a concentration-dependent manner. In particular, at 25 μg/mL concentration, melanin biosynthesis was more effectively inhibited by AARE (28.4%) than arbutin (24.7%; a well-known melanin synthesis inhibitor). In clinical trials, we investigated the changes in human skin brightness values over eight weeks using a cream formulation that contained 2% AARE after inducing pigmentation via ultraviolet irradiation. We showed that the hyperpigmentation degree, melanin index, and skin brightness were significantly improved.
AARE is expected to become widely available as a functional cosmetic material for skin whitening.
Key words: Anemarrhena asphodeloides, Tyrosinase, Natural depigmentation agent, Skin brightness, Melanin
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