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Asian J Beauty Cosmetol > Accepted Articles

doi: https://doi.org/10.20402/ajbc.2017.0195    [Accepted]
Anti-inflammatory Effect of Galium aparine Extract in RAW 264.7 Cells
Joong Hyun Shim
Faculty of Cosmetics and Beauty Biotechnology, Semyung University, Jecheon-si, Chungcheongbuk-do, Korea
Corresponding author:  Joong Hyun Shim ,Tel: +82 43 649 1615 , Fax: +82 43 649 1730, Email: jhshim@semyung.ac.kr
Received: November 8, 2017;  Accepted: February 20, 2018.  Published online: June 30, 2018.
ABSTRACT
Purpose:
This study was performed to identify the skin anti-inflammatory effect of Galium aparine (GA) extract on RAW 264.7 cells.
Method:
To investigate anti-inflammatory effects of GA on RAW 264.7 cells, we measured 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, cell viability, mRNA expressions, nitric oxide (NO), and prostaglandin E2 (PGE2) production.
Results:
In this study, we elucidated anti-inflammatory effects of GA extract on interleukin 1α (IL1α), interleukin 1 β (IL1β) interleukin 6 (IL6), and tumor necrosis factor α (TNFα) mRNA expression and NO production. Quantitative real-time polymerase chain reaction (qRT-PCR) showed that the GA extract decreased mRNA expression level of IL1α, IL1β, IL6, and TNFα and detection of NO and PGE2 also revealed that GA induces anti-inflammatory effects.
Conclusion:
Therefore, we successfully identified the anti-inflammatory effect of GA extract, and this result showed that the GA extract can be a potent cosmetic ingredient for anti-inflammatory and atopic dermatitis. Based on this, we anticipate further studies on the GA extract to determine a mechanism for developing not only cosmetics but also healthcare food or medicines.
Key words: Galium aparine, Radical scavenging, Anti-inflammatory, Nitric oxide, PGE2
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