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Kor J Aesthet Cosmetol > Volume 10(1); 2012 > Article
Kor J Aesthet Cosmetol 2012;10(1): 91-97.
흑삼의 아토피 억제활성에 대한 연구
신영진, 장현희, 송규용
Study on Anti-atopic Effects of Black Ginseng
Young Jin Shin, Hyun Hee Jang, Gyu Yong Song
The purpose of this study is to investigate the influence of black ginseng (BG) on induced IL-6, IL-8 and MCP- 1 secretion by house dust mite in THP-1 (human acute monocytic leukemia cell line) and EoL-1 (human eosinophilic leukemic cells) cell lines. The house dust mite (Dermatophagoides pteronissinus, D. pteronissinus ) plays a key role in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. Monocyte chemoattractant protein 1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) play a pivotal role in mediating the infiltration of various cells into the skin of atopic dermatitis. The korean ginseng (radix and leaf) was steamed to 3 hr at 120℃ under high pressure. The contents of benzopyrene which was known as a tumor promoting agent were analysed. Also, the inhibitory effect of BG on the induced IL-6, IL-8 and MCP-1 secretion by D. pteronissinus extract (DpE) in THP-1 and MCP-1 cells was examined. The BG extract (radix and leaf) potently suppressed the elevated production of IL-6 and IL-8 induced by DpE treatment in THP-1 and EoL-1 cells. Among them, the crude saponin fraction of BG leaf exhibited the most potent inhibitory activity. Based on the present results, it can be suggested that the 3 hr steaming at 120℃ under high pressure is the most optimal processing condition and BG may be useful to develop functional food on atopic dermatitis.
Key words: Black ginseng, Anti-atopic effect, IL-6, IL-8, MCP-1
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