| MAL추출물이 고콜레스테롤 식이를 급여한 토끼의 콜레스테롤 대사에 미치는 영향 |
| 박종배, 이혜숙, 황석연, 홍승복, 김희동, 윤치영 |
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| Effect of MAL Extracts on Cholesterol Metabolism in High Cholesterol Fed Rabbits |
| Jong-Bae Park, Hye-Sook Lee, Seock-Yeon Hwang, Seung-Bok Hong, Hee-Dong Kim, Chi-Young Yun |
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| ABSTRACT |
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To investigate the effect of MAL(plant extracts) on cholesterol metabolism, male New Zealand
White rabbits which were fed on high-cholesterol diet for 2 weeks were divided into the following 5
groups and fed on the experimental diet for 8 weeks : a normal diet group(ND, n=6), a high-cholesterol
diet group(HCD, n=6), a high-cholesterol diet and lovastatin0.002%(HCD+lovastatin0.002%, n=6),
a high-cholesterol diet and MAL 1% group(HCD+MAL1%, n=6), a high fat diet and MAL3%
group(HCD+3%, n=6). The levels of blood total cholesterol, LDL-cholesterol and HDL-cholesterol
were greatly increased by 2 weeks feeding on the high-cholesterol diet, compared with those of rabbits
fed on normal diet. Blood concentrations of total cholesterol and LDL-cholesterol increased in
HCD group after 8 weeks, whereas HDL-cholesterol significantly decreased. In the HCD+lovastatin0.002%
group, the levels of blood total cholesterol, triglycerides and LDL-cholesterol were significantly
reduced but there was no significant change in HDL-cholesterol. In the HCD+MAL1%
group, the levels of blood triglyceride was decreased, but not in blood concentrations of total
cholesterol. In the HCD+MAL3% group, the levels of blood total cholesterol and LDL-cholesterol reduced,
in addition to less-severe decrease in HDL-cholesterol. The level of ALT and AST significantly
increased in the HCD+lovastatin0.002% group, but not in groups fed MAL diets. These results
suggest that MAL may improve lipid metabolism of serum and potentially reduce lipid storage. |
| Key words:
plant extracts, high-cholesterol diet, total cholesterol, triglyceride |
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