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Kor J Aesthet Cosmetol > Volume 8(1); 2010 > Article
Kor J Aesthet Cosmetol 2010;8(1): 99-109.
DCS-HT®의 4주 반복투여 경피독성시험
이혜숙, 황석연
Four Week Repeated-Dose Dermal Toxicity Study of DCS-HT®
Hye-Sook Lee, Seock-Yeon Hwang
ABSTRACT
The purpose of this study was to investigate the four week repeated-dose toxicities of DCS-HT, a hair growth promoting agent which is composed of several plant extracts(β-sitosterol, moraceae, polygonum multiflorum thunberg, 3:1:1), in ICR mice. In the repeated dermal toxicity study, the test substances were administerd on the dermal of male and female ICR mice at dose levels of 10, 20, 40%(in distilled water, 1㎖) for 28 days. The results showed that there were not significantly different from control group in body weight gain, food intake, water consumption, relative organ weights, hematology findings and serum biochemistry findings at dose levels of DCS 10, 20%. Also we observed no death and abnormal clinical signs were observed during the experimental period. However, in 40% DCS group, there were statistical significance in body weight gain, food intake, water consumption and relative organ weights. From these results, NOAEL(no-observed-adverse-effect level) of DCS-HT in ICR mice is estimated to be 20%.
Key words: DCS, NOAEL(no-observed-adverse-effect level), MTD(maximum tolerated dose), repeated dermal toxicity
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