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Kor J Aesthet Cosmetol > Volume 8(1); 2010 > Article
Kor J Aesthet Cosmetol 2010;8(1): 111-120.
울금의 항산화 및 미백효과
박은영, 허선정, 김경영, 황완균, 양기숙
Anti-oxidant and Whitening Effects of Curcuma longa L.
Eun-young Park, Sun-jung Hur, Kyoung-young Kim, Wan-kyun), Whang, Ki-sook Yang
To search for new skin-lighting agents, the inhibitory property of Curcuma longa extract and five fractions (hexane, dichloromethane, ethylacetate, butanol, water) on melanogenesis and antioxidative activities were investigated. The inhibitory action of Curcuma longa extracts and fractions on mushroom tyrosinase was revealed. To explore the action of extracts and fractions on melanogenesis, the inhibition of tyrosinase and melanin contents were measured in B16F10 melanoma cells. Results show that ethylacetate>methanol>butanol>dichloromethane>hexane fractions of Curcuma longa has strong antioxidative activities, IC50 was 8.01 μg/mL (ascorbic acid IC50 10.76 μg/mL). Inhibition of tyrosinase activity, ethylacetate fraction of Curcuma longa was IC50 31.40μg/mL(ascorbic acid IC50 16.06 μg/mL). Also, ethylacetate fraction of Curcuma longa reduced melanin contents in B16F10 cells. Therefore, this data indicate Curcuma longa as a potential pigmentation reagents.
Key words: Curcuma longa, Antioxidant, Tyrosinase, Melanoma cell
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