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Kor J Aesthet Cosmetol > Volume 11(1); 2013 > Article
Kor J Aesthet Cosmetol 2013;11(1): 29-34.
3T3-L1 세포에서 Adipogenesis 조절을 통한 Demethoxycurcumin의 항비만 활성
김혜옥, 황용일, 김교남
Anti-obese Function of Demethoxycurcumin through Suppression of Adipogenesis in 3T3-L1 Cells
Hae Ok Kim, Yong-Il Hwang, Gyo-Nam Kim
ABSTRACT
Obesity is a major health problem and it also closely associated with metabolic disorders. Adipogenesis was defined as a differentiation process of preadipocytes into adipocytes. Thus, adipogenesis is a potential target to treat or prevent obesity. Demethoxycurcumin (DCCM) has been reported to possess potent antioxidant and proapoptotic properties. However, its role in obesity prevention remains unknown. Here, we demonstrate the potential role of DCCM in 3T3-L1 cells. We found that 1-50 μM of DCCM showed no effect on the viability of 3T3-L1 preadipocytes. We also found DCCM dose-dependently inhibited adipogenesis, accompanied by reduced level of adipogenic transcriptional factors such as C/EBPβ and PPARγ. Our results implicate that the inhibitory action of DCCM is strongly linked to the reduction of C/EBPβ and PPARγ. These evidences provide useful information for the development of obesity-related nutri-cosmetics design.
Key words: Obesity, Demethoxycurcumin, Adipogenesis, 3T3-L1, Nutri-cosmetics
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