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Kor J Aesthet Cosmetol > Volume 7(3); 2009 > Article
Kor J Aesthet Cosmetol 2009;7(3): 131-141.
C57BL/6마우스 모델에서 DCS-HT® 발모제의 모발성장 촉진 효과
이혜숙, 황석연
Effects of DCS® Hair Tonic on Hair growth promotion in an Alopecia Model of C57BL/6 Mice
Hye-Soo Lee, Seock-Yeon Hwang
ABSTRACT
DCS-HT® is a hair-care product which is composed of several plant extracts used in oriental medicine. This study was carried out to evaluate the effect of DCS-HT® on Hair growth in an alopecia model of C57BL/6 mice. Six weeks old male mice were divided into four groups including normal(saline), vehicle control group(50% ethanol), positive control group(3% minoxidil) and experimental group(DCS-HT®) and they applied to dorsal skin an amount of 150㎕ per mouse once a day for 21days. The hair regrowth was determined photographically and histologically during the experimental period of 21 days. The activities of enzyme including alkaline phosphatase and γ-Glutamyl transpeptidase and the quantity of IGF-1 and TGF-β expression in the skin of C57BL/6 mice were also determined using a rate assay method. There were no clinical signs in all groups. The topical treatment of DCS hair tonic and 3% Minoxidil significantly accelerated hair regrowth faster than the other groups(p<0.05). ALP and γ-GT activities after 21days were significantly increased in DCS-HT®(p<0.01). And DCS hair tonic and 3% Minoxidil were significantly increased the expression of IGF-1 in the skin of C57BL/6 mice(p<0.01). These results suggest that DCS-HT® has hair growth promoting activities and it can be used for treatment for alopecia.
Key words: Alopecia, DCS-HT®, Enzyme activities
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