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Kor J Aesthet Cosmetol > Volume 11(6); 2013 > Article
Kor J Aesthet Cosmetol 2013;11(6): 1067-1072.
3T3-L1 세포 모델에서 Adipogenesis 조절을 통한 녹색입 홍합 추출물의 항비만 활성
손명수, 김시경, 이승철, 김교남
Anti-obese Activity of Water Extract Prepared from Green-shelled Mussel through Regulating Adipogenesis
Myung-Soo Shon, Si-Kyung Kim, Seung-Cheol Lee, Gyo-Nam Kim
ABSTRACT
Adipogenesis was defined as a differentiation process of preadipocytes into adipocytes. It is a key process in determining the number of mature adipocytes in the development of obesity. Thus, to regulation of adipogenesis is crucial target in obesity prevention. Mussel (Mytilus corscus) has been reported to possess abundant dietary proteins and savory amino acids. However, antiadipogenic role and function in obesity prevention remains unknown. Here, we employed green-shelled mussel and its water extract (GME) was prepared. To elucidate the potential role of GME in 3T3-L1 adipogenesis, 3T3-L1 cells were treated with GME between day –2 to day 6. We found that GME dose-dependently suppressed adipogenesis and inhibited formation of lipid droplets accompanied by reduced level of adipogenic transcriptional factors such as C/EBPα and FAS. Our study further revealed that inhibitory function of GME wa largely limited to the adipogenesis day 0 to day 6. Taken together, our evidences provide new insights into the molecular basis underlying the antiadipogenic function of GME.
Key words: Obesity, Adipogenesis, Green-shelled mussel, 3T3-L1, Adipogenic genes
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