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Kor J Aesthet Cosmetol > Volume 12(6); 2014 > Article
Kor J Aesthet Cosmetol 2014;12(6): 831-836.
활성산소종(Reactive Oxygen Species)으로 유도된 인간진피섬유아세포 손상에 대한 루틴(Rutin)의 항산화 효과
The Antioxidant Effect of Rutin in Human Dermal Fibroblasts Damaged by Reactive Oxygen Species
Sung Nae Lee
The reason why Reactive oxygen species (ROS) generate in a cell is harmful substances from exterior cell. In the human body, most of the free radicals disappear by creating an oxidation inhibitor. But oxidative stress is induced when ROS can not be removed by former defenser. Oxidative stress causes DNA denaturation, destruction of the cell membrane, Hardening of the arteries and cellular senescence, directly or indirectly. Rutin, glycosides of quercetin, is the flavonoid-based compound which is widely distributed in the plant kingdom. Rutin was shown to strengthen capillaries and capillary action contraction is used as the main component of the circulatory disease treatment and hypertension. In this study, we demonstrated that pretreatment of rutin protects human dermal fibroblasts (NHDFs) from the oxidative stress. Additional biochemical assay showed that rutin has ROS scavenging effect and furthermore, alters mRNA expression of SOD1 and CAT in NHDFs. Our results indicate that rutin is implicated as a potential biochemical or chemopreventive agent through phenomenas from oxidative stress in NHDFs.
Key words: Rutin, ROS, H2O2, SOD1, CAT
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