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Kor J Aesthet Cosmetol > Volume 12(6); 2014 > Article
Kor J Aesthet Cosmetol 2014;12(6): 939-944.
인간진피섬유아세포에서 Nobiletin이 Mitogen-Activated Protein Kinases를 통한 Matrix-Metalloprotease 1 발현조절에 미치는 영향
차화준, 김영주
Mitogen-Activated Protein Kinases Mediated Regulation of Matrix-Metalloprotease 1 by Nobiletin in Human Dermal Fibroblasts
Hwa Jun Cha, Young-Joo Kim
ABSTRACT
Nobiletin is widely used for the treatment of cancer and inflammation disorder. In neurocytes and melanocytes, nobiletin exposure induced dendrite formation. Recently, nobiletin is suggested as a new whitening agent. However, in dermis, effects of nobiletin are not understood currently. Therefore, it is important to determine how nobiletin exerts its therapeutic action and its effect on the anti-wrinkle. To determine whether MMP1 gene expression is regulated by nobiletin, we measured MMP1 mRNA expression in nobiletein-treated human dermal fibroblasts (HDFs). And we showed that transactivation activity of TPA responsive element (TRE) which is a major regulation promoter element and mitogen-activated protein kinase (MAPK) activity which main regulator of AP-1 complex. As shown results, nobiletin was decrease expression level of MMP1 mRNA in oxidative-stressed HDFs. In addition, nobiletin repressed MAPK phosphorylation and transcriptional activity of AP-1 complex in oxidative-stressed HDFs. Therefore, nobiletin protects oxidative-stress through repressing MAPK phosphorylation and transcriptional activity of AP-1 complex. In addition, these results suggest that nobiletin is a potential cosmetic ingredient repressed antiaging and anti-wrinkle in skin.
Key words: Nobiletin, Human dermal fibroblasts, Matrix-metalloprotease 1
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