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Kor J Aesthet Cosmetol > Volume 13(4); 2015 > Article
Kor J Aesthet Cosmetol 2015;13(4): 469-476.
마늘추출물 함유 화장료의 피부 기능성 효과 : 항산화 및 콜라게나제, 엘라스타제와 티로시나제의 억제 효과를 중심으로
김영숙, 정은영, 고혜정, 홍양희
Effects of Formulation Containing Garlic Extract on Functional Skin Care: Antioxidation and Inhibitive Activities of Collagenase, Elastase and Tyrosinase
Young Suk Kim, Eun Young Jung, Hyea Jung Koh, Yang Hee Hong
ABSTRACT
We was to evaluate the physiological effects of formulation containing garlic extract on skin care. The total polyphenol (p<.001), flavonoid (p<.001) contents and 1,1-diphenyl–2-picrylhydrazyl (DPPH) (p<.001), 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) (p<.01) radicals scavenging activities and reducing power (p<.05) of the garlic formulation were significantly higher compared to those of the base formulation. The inhibition of collagenase (p<.05) of the garlic formulation were significantly higher compared to those of the base formulation. Specially, the base formulation inhibited slightly elastase activity whereas the garlic formulation had about 8-fold higher elastase inhibitory activity (p<.001). When the garlic extract was added to the formulation, the tyrosinase activity was decreased significantly (p<.05, p<.01, p<.001). In conclusion, the garlic formulation had high inhibitory activities for tyrosinase and elastase, thus suggesting that garlic may have beneficial properties as a material for cosmeceuticals.
Key words: Garlic formulation, Antioxidant effects, Collagenase, Pancreatic elastase, Tyrosinase
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