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Kor J Aesthet Cosmetol > Volume 13(6); 2015 > Article
Kor J Aesthet Cosmetol 2015;13(6): 813-818.
인간각질형성세포에서 알파망고스틴의 자외선B 의존적 산화적 스트레스에 대한 세포보호 효과
고정민
Protective Effects of α-Mangostin on UVB-induced Oxidative Stress and Cellular Senescence
Jung-Min Ko
ABSTRACT
One of subtypes in ultraviolet (UV), UVB, has been reported that the most powerful factors causing photoaging and DNA lesions. Finding and developing both cost-effective and efficient materials are the urgent issues to protect the skin from UVB-induced damages. Alpha-mangostin (α-mangostin), the first xanthone isolated from Garcinia mangostana (mangosteen), has been studied for anti-inflammation and antioxidant properties. The purpose of this study to investigate effects of α-mangostin in HaCaT, keratinocyte against UVB radiation. To evaluate effects of α-mangostin upon UVB-induced cytotoxic damages, watersoluble tetrazolium salt (WST-1) assay, flow Cytometry analysis, qunatitative real-time PCR (qRT-PCR), and senescence associated β-galactosidase assay (SA-β-gal assay) were performed. Pretreatment of α-mangostin was verified protective effects on UVB-induced proliferative restrain, apoptotic cell death and senescence, in HaCaT keratinocytes. These results indicated the protective effects of α-mangostin against UVB, and suggest as a cosmeceutical ingredient.
Key words: α-Mangostin, Ultraviolet B, Keratinocyte, Senescence, Oxidative stress
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