Asian J Beauty Cosmetol. 2011; 9: 0.
Anti-Aging Effects of Resveratrol
ABSTRACT
This study is aiming at authenticating and approaching the function of resveratrol in delaying aging by observing the its effects to the activity of T-SOD in serum, the content of MDA in skin
tissue and change in skin stucture of the naturally aging mouse. In the experiment, we took 12
healthy kunming mice at age of 4months as young control(A). 60healthy kunming mice at age of
18months was randomly divided into 5groups as following: old blank control group(B), old positive
medicine control group(C), old gypenoside control group(D), old resveratrol HD group (E) and old
resveratrol LD group (F). Deal the mice with intragastric administrating Group A and Group B
with N.S (20ml/kg, qd), Group C with mixture of VE & VC (30mg/kg, qd), Group D with suspl.
Gypenoside (30mg/kg, qd), and Group E & F with suspl. Resveratrol (30mg/kg, qd for
HD;10mg/kg, qd for LD). The mice was put to death and drawn the material from on the
31stDay.ThenwedeterminethecontentofT-SODandMDAbybiochemistry analytical method and applied
technic of histopathologic slide to observe the corium structure (HE coloretur, 100×light microscope).
Biochemistry result shows that T-SOD activity of naturally aging mouse decreased, while the MDA
in the skin tissue increased, and resveratrol may promote the T-SOD activity and depress the
content of MDA. Observed by light microscope the skin of mice in Group B-F shows apolexis
compared with young control group and the status of mice in Group C-F shows surpass to that of
old blank group, but can’t get the same status as that of the young control group.
Keywords :
resveratrol, aging, free radicals, T-SOD(total superoxide dismutase), MDA(malonicdialdehydel)
