Asian J Beauty Cosmetol. 2012; 10(4): 961-968.
Inhibition of Melanogenesis and Anti-UV properties Reynoutria elliptica
ABSTRACT
Reynoutria elliptica is Asian as traditional herbal medication. In this study, we examined the Inhibition of
melanogensis and anti-UV properties ethanol extract of R. elliptica. Total polyphenols and flavonoids contents
of R. elliptica, the result was respectively 209.2±1.2, 83.4±2.0 mg/g. Electron-donating ability of ethanol extract
of R. elliptica was in 400 ㎍/㎖ as 92.92±1.51%. Tyrosinase have suppress effect in a dose dependent. UVblocking
effect was also showed a strong UV absorption in the range of UV-A(350-370 ㎚). In addition we
tested tyrosinase inhibition activity and melanin contents on SK-MEL-2. Tyrosinase was inhibited to 40% at
the dose of 20 ㎍/㎖ and melanogenesis was inhibited was 30%. Overall, our results indicate that R.elliptica
extract showed that the α-MSH-mediated upregulation of tyrosinase activity and melanogenesis were inhibited
in the extract does dependent manner in Sk-MEL-2 cells. Hence, R. elliptica extract could be applied as a type
of dermatological whitening and anti-UV agent in skin care products.
Keywords :
Anti-UV, SK-MEL-2, Tyrosinase, Melanin
