Asian J Beauty Cosmetol. 2009; 7(3): 131-141.
Effects of DCS® Hair Tonic on Hair growth promotion in an Alopecia Model of C57BL/6 Mice
ABSTRACT
DCS-HT® is a hair-care product which is composed of several plant extracts used in oriental medicine. This study was carried out to evaluate the effect of DCS-HT® on Hair growth in an alopecia model of C57BL/6 mice. Six weeks old male mice were divided into four groups including normal(saline), vehicle control group(50% ethanol), positive control group(3% minoxidil) and experimental group(DCS-HT®) and they applied to dorsal skin an amount of 150㎕ per mouse once a day for 21days. The hair regrowth was determined photographically and histologically during the experimental period of 21 days. The activities of enzyme including alkaline phosphatase and γ-Glutamyl transpeptidase and the quantity of IGF-1 and TGF-β expression in the skin of C57BL/6 mice were also determined using a rate assay method. There were no clinical signs in all groups. The topical treatment of DCS hair tonic and 3% Minoxidil significantly accelerated hair regrowth faster than the other groups(p<0.05). ALP and γ-GT activities after 21days were significantly increased in DCS-HT®(p<0.01). And DCS hair tonic and 3% Minoxidil were significantly increased the expression of IGF-1 in the skin of C57BL/6 mice(p<0.01). These results suggest that DCS-HT® has hair growth promoting activities and it can be used for treatment for alopecia.
Keywords :
Alopecia, DCS-HT®, Enzyme activities
