Asian J Beauty Cosmetol. 2015; 13(4): 469-476.
Effects of Formulation Containing Garlic Extract on Functional Skin Care: Antioxidation and Inhibitive Activities of Collagenase, Elastase and Tyrosinase
ABSTRACT
We was to evaluate the physiological effects of formulation containing garlic extract on skin care. The total polyphenol (p<.001), flavonoid (p<.001) contents and 1,1-diphenyl–2-picrylhydrazyl (DPPH) (p<.001), 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) (p<.01) radicals scavenging activities and reducing power (p<.05) of the garlic formulation were significantly higher compared to those of the base formulation. The inhibition of collagenase (p<.05) of the garlic formulation were significantly higher compared to those of the base formulation. Specially, the base formulation inhibited slightly elastase activity whereas the garlic formulation had about 8-fold higher elastase inhibitory activity (p<.001). When the garlic extract was added to the formulation, the tyrosinase activity was decreased significantly (p<.05, p<.01, p<.001). In conclusion, the garlic formulation had high inhibitory activities for tyrosinase and elastase, thus suggesting that garlic may have beneficial properties as a material for cosmeceuticals.
Keywords :
Garlic formulation, Antioxidant effects, Collagenase, Pancreatic elastase, Tyrosinase
