| 생물전환된 소태나무 추출물의 항염증 및 신생혈관 억제효과: NF-κB 신호전달 경로 억제와 신생혈관 억제에 대한 연구 |
| 소경석1,2, 이존환2, 오한나3, 강희철4, 서원상4, 김용우5, 배승희1 |
1건국대학교 화장품공학과 질병분자표적신약연구소, 서울, 한국
2씨엔에프 군포캠퍼스 기술연구소, 경기도 군포시, 한국
3JW중외제약 마케팅연구개발부, 경기도 과천시, 한국
4GFC생명과학 연구소, 경기도 화성시, 한국
5동국대학교 화공생물공학과, 서울, 한국 |
| Anti-inflammatory and Anti-angiogenic Effects of Bioconverted Picrasma quassioides Extract: A Comparative Study on NF-κB Signaling Pathway Inhibition and Angiogenesis Suppression |
| Kyeong-Seok So1,2, John Hwan Lee2, Hanna Oh3, Hee-Cheol Kang4, Wonsang Seo4, Yong-Woo Kim5, Seunghee Bae1 |
1Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk University, Seoul, Korea
2Technology Research Institute, Gunpo Campus, CNF, Gunpo-si, Gyeonggi-do, Korea
3Marketing Research and Development Department, JW Pharmaceutical, Gwacheon-si, Gyeonggi-do, Korea
4Materials Division Affiliated Research Center, GFC Life Science, Hwaseong-si, Gyeonggi-do, Korea
5Department of Chemical and Biological Engineering, Dongguk University, Seoul, Korea |
| 生物转化苦木提取物的抗炎和抗血管生成作用：NF-κB信号通路抑制和血管生成抑制的比较研究 |
| 蘇坰錫1,2, 李存桓2, 吳한나3, 姜熙哲4, 徐源祥4, 金勇佑5, 裵承煕1 |
1建国大学化妆品学科疾病分子靶标新药研究所，首尔，韩国
2CNF军浦区技术研究所，京畿道军铺市，韩国
3JW中外制药营销研究开发部，京畿道果川市，韩国
4GFC生命科学研究所，京畿道华城市，韩国
5东国大学化工生物工学科，首尔，韩国 |
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Received: July 4, 2024; Accepted: September 4, 2024. Published online: September 25, 2024. |
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| ABSTRACT |
Purpose:
This study aimed to compare the anti-inflammatory and anti-angiogenic properties of bioconverted Picrasma quassioides extract (B-P.Q) with those of the non-bioconverted extract (P.Q) and peony root bark extract (BOT).
Methods:
The research utilized several experimental techniques, including cell viability assays on NIH 3T3 fibroblasts, measurement of NF-κB-related signaling protein activation, chorioallantoic membrane (CAM) assays, tube formation assays, and cell migration inhibition assays using human umbilical vein endothelial cells (HUVECs). These methods were employed to evaluate cytotoxicity, anti-inflammatory effects, and anti-angiogenic properties of the extracts.
Results:
B-P.Q demonstrated no cytotoxicity at the tested concentrations and significantly inhibited the activation of NF-κB-related signaling proteins (p-p38, p-Akt-1, p-SAPK/JNK, p-MEK1/2, and p-IκB) compared to P.Q and BOT. In angiogenesis experiments, B-P.Q showed superior inhibition of new blood vessel formation in CAM assays, effectively suppressed tube formation, and significantly inhibited HUVEC migration compared to controls and P.Q.
Conclusion:
The study found that bioconverted Picrasma quassioides extract (B-P.Q) has strong anti-inflammatory and anti-angiogenic properties, consistently outperforming non-bioconverted P.Q and BOT in various experimental models. These results suggest that B-P.Q holds significant promise as a therapeutic agent for chronic inflammatory conditions, particularly those involving excessive angiogenesis. The research underscores the effectiveness of bioconversion in enhancing the bioactive properties of natural extracts and opens up new possibilities for developing treatments for inflammatory skin problems. |
| Key words:
Cosmetics, Bioconversion, Picrasma quassioides, NF-κB, CAM assays |
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