| SK-MEL-2에서 상백피 추출물의 Tyrosinase 활성 억제 및 Melanin 생성 억제 효과 |
| 유민정 |
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| Inhibitory Effect of Morus alba Extracts on Tyrosinase Activity and Melanogenesis in SK-MEL-2 cells |
| Min-Jeong Ryu |
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| ABSTRACT |
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This study was to investigate the ethanol extracts of Morus alba on tyrosinase activity and
melanogenesis. In the present study , we examined the effects of Morus alba ethanol extract on
mushroom tyrosinase activity in vitro, on SK-MEL-2 cell tyrosinase activity , melanin contents,
expression of melanogenic enzyme proteins including tyrosinase, tyrosinase-related protein1(TRP-1)
and and tyrosinase-related protein2(TRP-2). Mushroom tyrosinase activity of dose dependant and
about 75% at concentration of 400 ㎍/㎖. Morus alba ethanol extracts reduced melanin contents of
SK-MEL-2 melanoma cella in a dose dependant manner and decreased to about 83.2% at a cocentration
of 100 ㎍/㎖ without cell cytotoxicity(below 100 ㎍/㎖) and intracellular tyrosinase activity
about 54.2% at concentration of 100 ㎍/㎖. Morus alba ethanol extracts inhibited tyrosinase and
TRP-2 expression at protein level. These results suggest that Morus alba ethanol extracts reduced
melanin formation by the inhibitied of tyrosinase activity and expression in SK-MEL-2 melanoma
cells. Therefor, we confirmation that Morus alba ethanol extracts could be used as a useful
whitening agent. |
| Key words:
Morus alba, Whitening , SK-MEL-2, Tyrosinase, Melanin |
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