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Asian J Beauty Cosmetol > Accepted Articles

doi: https://doi.org/10.20402/ajbc.2017.0171    [Accepted]
Anti-microbial Activity and Anti-inflammatory Effects of Fucoidan Extracts
Ah Reum Lee1, Seong-Soo Roh1, Hyun-Kyoung Kim2
1College of Korean Medicine, Daegu Haany University, Daegu, Korea
2Department of Food Science and Engineering, Seowon University, Cheongju-si, Chungcheongbuk-do, Korea
Corresponding author:  Hyun-Kyoung Kim ,Tel: +82 43 299 8474 , Fax: +82 43 299 8470, Email: kimhk4@seowon.ac.kr
Received: August 5, 2017;  Accepted: January 11, 2018.  Published online: June 30, 2018.
ABSTRACT
Purpose:
This study aimed to evaluate fucoidan extract as a cosmetic material.
Method:
To assess anti-microbial efficacy, Staphylococcus aureus (S. aureus) was treated with fucoidan extract and zones of inhibition were measured. In addition, the anti-inflammatory effect was confirmed in RAW 264.7 cells, and fucoidan extract was applied to the dorsal skin of Sprague–Dawley (SD) rats to evaluate single dose toxicity.
Results:
Fucoidan extract did not exhibit cytotoxicity at concentrations up to 1,000 μg/mL in skin fibroblasts. Furthermore, when S. aureus was treated with 1% fucoidan extract, clear zones of 1.52±0.34 cm formed, confirming sufficient anti-microbial activity. When RAW 264.7 cells were treated with fucoidan extract, nitric oxide (NO) production decreased in a concentration-dependent manner and the production of inflammation-related cytokines, such as interleukin 1 beta (IL1β), tumor necrosis factor alpha (TNF), and prostaglandin E2 (PGE2), decreased. When fucoidan was applied at various concentrations to rats, symptoms did not change for more than 14 days, and there was no change in body or organ weights.
Conclusion:
Fucoidan extract is not cytotoxic and has anti-microbial and anti-inflammatory effects. Therefore, it is suitable for use as a cosmetic material.
Key words: Fucoidan, Cell toxicity, Anti-microbial efficacy, Anti-inflammatory effect, Dermal toxicity
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