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Kor J Aesthet Cosmetol > Volume 12(2); 2014 > Article
Kor J Aesthet Cosmetol 2014;12(2): 163-168.
B16F10 mouse melanoma 세포에서 삼채(Allium hookeri) 추출물의 멜라닌 형성 억제 효과에 관한 연구
최연선, 최태부
Melanogenesis Inhibitory Effects of Allium hookeri Extract in B16F10 Mouse Melanoma Cell
Yoensun Choe, Tae-Boo Choe
ABSTRACT
The effect of Allium hookeri extracts on the melanogenesis in mouse melanoma B16F10 was studied as a raw material of functional cosmetics. Allium hookeri has been associated with the traditional recipes of meiteis and also with the ethnotherapy of certain diseases by local herlers since the time immemorial, the plant has been regarded as ethnobotanic relevance to the Manipuris. The effect of Allium hookeri extracts has found that the secreted melanin in culture medium was reduced by 50% at the concentration of 0.064%. At this concentration, tyrosinase activity was reduced by 20%. On the other hand, Tyrosinase expression level was reduced by 93% at the same concentration comparing to the case of positive control. TRP1 and TRP2 expression levels were also reduced as much as 70%. The expression levels of the enzymes necessary for the melanogenesis were confirmed by western blotting. This is the first study about melanogenesis inhibitory effect of Allium hookeri extracts. However, it is not yet clear which compound is effective in anti-melanogenesis. Further studies are necessary to elucidate the detail mechanism.
Key words: Melanogenesis, Allium hookeri, Tyrosinase, Whitening, Functional cosmetics
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