| Melanin Synthesis Gene Inhibition Effect through Inhibition of Tyrosinase and TRPs Expression of Coriandrum sativum-derived Exosome |
| Ha young Park, Seon Young Lee, Min Ho Kang, Jung Eun Park, Jin Woo Kim |
| Department of Food Science, Sunmoon University, Asan-si, Chungcheongnam-do, Korea |
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Received: March 20, 2024; Accepted: August 8, 2024. Published online: August 8, 2024. |
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| ABSTRACT |
Purpose:
This study investigated the skin-whitening effects achieved through suppressing melanin synthesis using exosomes derived from Coriandrum sativum (C. sativum).
Methods:
We examined the characteristics of C. sativum exosomes (CSEs) using nanoparticle tracking analysis, which revealed an average size of 152.3 nm and a concentration of 3.0×1010 particles/mL. A cytotoxicity evaluation was conducted on B16F0 cells to assess cellular safety of CSEs. We investigated the skin-whitening effects of CSEs by quantifying melanin synthesis gene expression using RT-PCR.
Results:
CSE concentrations less than 1.5 × 108 particles/mL did not negatively affect cellular activity. Furthermore, CSE treatment significantly decreased the expression of key genes involved in melanin synthesis such as tyrosinase, TRP-1, and TRP-2 by 75.6%, 89.1%, and 88.7%, respectively.
Conclusion:
CSEs hold promise as functional cosmetic ingredients that promote skin whitening by inhibiting key genes involved in melanin production. |
| Key words:
Coriandrum sativum, Exosome, Melanin, Tyrosinase, Skin-whitening |
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