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Asian J Beauty Cosmetol > Volume 22(3); 2024 > Article
Asian Journal of Beauty and Cosmetology 2024;22(3): 393-402.
doi: https://doi.org/10.20402/ajbc.2024.0018
고수 엑소좀의 Tyrosinase와 TRPs 발현 억제를 통한 피부 미백 증진 효과
박하영, 이선용, 강민호, 박정은, 김진우
선문대학교 식품과학과, 충청남도 아산시, 한국
Melanin Synthesis Gene Inhibition Effect through Inhibition of Tyrosinase and TRPs Expression of Coriandrum sativum-derived Exosome
Ha young Park, Seon Young Lee, Min Ho Kang, Jung Eun Park, Jin Woo Kim
Department of Food Science, Sunmoon University, Asan-si, Chungcheongnam-do, Korea
通过抑制芫荽来源的外泌体的酪氨酸酶和TRPs表达来抑制黑色素合成基因
朴荷泳, 李先鏞, 康民湖, 朴正恩, 金鎭佑
鲜文大学食品科学科,忠淸南道牙山市,韩国
Corresponding author:  Jin Woo Kim ,Tel: +82 41 530 2278 , Fax: +82 41 530 2114, Email: kimjw1028@sunmoon.ac.kr
Received: March 20, 2024;  Accepted: August 1, 2024.  Published online: August 8, 2024.
ABSTRACT
Purpose:
This study investigated the skin-whitening effects achieved through suppressing melanin synthesis using exosomes derived from Coriandrum sativum (C. sativum).
Methods:
We examined the characteristics of C. sativum exosomes (CSEs) using nanoparticle tracking analysis, which revealed an average size of 152.3 nm and a concentration of 3.0×1010 particles/mL. A cytotoxicity evaluation was conducted on B16F0 cells to assess cellular safety of CSEs. We investigated the skin-whitening effects of CSEs by quantifying melanin synthesis gene expression using RT-PCR.
Results:
CSE concentrations less than 1.5×108 particles/mL did not negatively affect cellular activity. Furthermore, CSE treatment significantly decreased the expression of key genes involved in melanin synthesis such as tyrosinase, TRP-1, and TRP-2 by 75.6%, 89.1%, and 88.7%, respectively.
Conclusion:
CSEs hold promise as functional cosmetic ingredients that promote skin whitening by inhibiting key genes involved in melanin production.
Key words: Coriandrum sativum, Exosome, Melanin, Tyrosinase, Skin-whitening
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