| 고수 엑소좀의 Tyrosinase와 TRPs 발현 억제를 통한 피부 미백 증진 효과 |
| 박하영, 이선용, 강민호, 박정은, 김진우 |
| 선문대학교 식품과학과, 충청남도 아산시, 한국 |
| Melanin Synthesis Gene Inhibition Effect through Inhibition of Tyrosinase and TRPs Expression of Coriandrum sativum-derived Exosome |
| Ha young Park, Seon Young Lee, Min Ho Kang, Jung Eun Park, Jin Woo Kim |
| Department of Food Science, Sunmoon University, Asan-si, Chungcheongnam-do, Korea |
| 通过抑制芫荽来源的外泌体的酪氨酸酶和TRPs表达来抑制黑色素合成基因 |
| 朴荷泳, 李先鏞, 康民湖, 朴正恩, 金鎭佑 |
| 鲜文大学食品科学科，忠淸南道牙山市，韩国 |
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Received: March 20, 2024; Accepted: August 1, 2024. Published online: August 8, 2024. |
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| ABSTRACT |
Purpose:
This study investigated the skin-whitening effects achieved through suppressing melanin synthesis using exosomes derived from Coriandrum sativum (C. sativum).
Methods:
We examined the characteristics of C. sativum exosomes (CSEs) using nanoparticle tracking analysis, which revealed an average size of 152.3 nm and a concentration of 3.0×1010 particles/mL. A cytotoxicity evaluation was conducted on B16F0 cells to assess cellular safety of CSEs. We investigated the skin-whitening effects of CSEs by quantifying melanin synthesis gene expression using RT-PCR.
Results:
CSE concentrations less than 1.5×108 particles/mL did not negatively affect cellular activity. Furthermore, CSE treatment significantly decreased the expression of key genes involved in melanin synthesis such as tyrosinase, TRP-1, and TRP-2 by 75.6%, 89.1%, and 88.7%, respectively.
Conclusion:
CSEs hold promise as functional cosmetic ingredients that promote skin whitening by inhibiting key genes involved in melanin production. |
| Key words:
Coriandrum sativum, Exosome, Melanin, Tyrosinase, Skin-whitening |
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