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Kor J Aesthet Cosmetol 2005;3(1): 125-130. |
| Phytosphingosine이 첨가된 리포좀의 P. acne 와 S. aureus 에 대한 항균력 조사 |
| 한상희, 임미혜, 이연희, 최연선, 최태부 |
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| Antimicrobial effect of Phytosphingosine containing liposome
against P. acne and S. aureus |
| Sang-Hee Han, Mi-Hyea Leem, Yeon-Hee Lee, Yeon-Sun Choi, Tae Boo Choe |
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| ABSTRACT |
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As the whole world's Cosmeceutical products market scale is getting huge gradually which
aim to improve acne, atopy, psoriasis. thus it is accelerating the development of a research on
the naturally antibiotic ingredients that are harmless to the human body.
As Phytosphingosine (hereunder called PS) is the natural antibiotic ingredient that exists
with 1∼2% in the stratum corneum of the skin, this study researched monovalence, with PSL,
which was made of liposome. As a result of that, P. acnes, which is the causative organism
of acne, S. aureus which is the causative organism of atopy showed the monovalence of more
than 99% in the concentration 25㎍/㎖. Therefore, PS hampers the growth of P. acnes and S.
aureus shows the monovalence. thus it seems that the possibility of applying PS as the
antibiotic ingredient, will get higher. Also, as a result of experimenting with PSL in order to
be able to use PS, which is insoluble, more effectively, the monovalence is shown even in the
design of liposome, thus this study considers it desirable to use as the design of liposome,
which increases the efficiency for the skin delivery system of PS, and suggests the feasibility
of using cosmetics to improve acne on the basis of this, and it is thought to be expanded the
range of utilizing the application of cosmetics as hypoallergenic antibiotic ingredient. |
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