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Kor J Aesthet Cosmetol > Volume 12(5); 2014 > Article
Kor J Aesthet Cosmetol 2014;12(5): 597-605.
화장품의 경피 흡수에 대한 최신 연구 동향
정지연, 한효선
The Recent Trend of Percutaneous Absorption Used in Cosmetics
Ji-Yeon Chung, Hyo-Sun Han
ABSTRACT
The formidable barrier property of the stratum cornemum and the high hydrophilicity of active ingredient make it difficult to permeate through the skin and reach to its site of action. So the interest of cosmetic industry is how to promote percutaneous absorption of active ingredients. The aim of this study was to analysis and organize theses on percutaneous absorption of active ingredient. Physical penetration enhancers on the skin permeation is iontophoresis, electroporation, sonophoresis, tape stripping, and so on. A physical penetration enhancer that has received greater attention lately is MTS (Microneedle Therapy System). This therapy uses micro-needle which is equipped with very thin, delicate needles smaller than a 0.07 mm thick hair. During this therapy, the micro-needle makes small holes and helps absorb the solution into the skin. But the penetration enhancers on the skin permeation that has received the greatest attention since 2005 is a hoof shape method, such as pH-responsive P (MAA-co-PEGMA) hydrogel, micelle, nano emulsion, liposome, ethosome. Especially, theses on nano emulsion and liposome (including ethosome) hold a large majority. According to the theses, the ethosome exhibited more enhanced skin permeability than general liposome and ethanol solution.
Key words: Percutaneous absorption, MTS, Nano emulsion, Liposome, Ethosome
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