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Kor J Aesthet Cosmetol > Volume 12(5); 2014 > Article
Kor J Aesthet Cosmetol 2014;12(5): 733-743.
기능성 소재 개발을 위한 돼지태반추출물의 경구 및 피부 동물모델 안정성 평가
홍양희, 정은영, 서형주
Oral and Topical Safety Evaluation of Porcine Placenta Extract for the Development of the Functional Ingredient Using Animal Models
Yang-Hee Hong, Eun Young Jung, Hyung Joo Suh
ABSTRACT
Animal-derived placenta extract (PE) are available commercially and regularly used in various ointments and lotions for the purpose of improving skin properties. Although the effects of PE have been largely studied, only a few scientific studies report the skin safety evaluations of PE derived from animals such as pig. The objective of this study was to evaluated the anti-aging potential and safety of collagen in subcritical extract of porcine homogenate of placenta (SPE) for nutricosmetic and cosmeceutical ingredients. The experimental animals were divided into 6 groups, and were treated for 12 wks: positive control group (PO) treated with no-ultra violet (UV)B, negative control group (NO) treated with only UVB, experimental group 1 (OSPE-1) low dosage oral application treated with SPE, experimental group 2 (OSPE-2) high dosage oral application treated with SPE, experimental group 3 (OSPE-1+FSPE-1) low dosage oral and topical application treated with SPE, and experimental group 4 (OSPE-2+FSPE-2) high dosage oral and topical application treated with SPE. The serum biochemical markers for liver, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were also not affected by the application of SPE at any groups. But OSPE-2+FSPE-2 had significant (p<.05) decreased in lactate dehydrogenase (LDH) level compared than NO. The skin safety was performed to evaluate of potential toxicity using the primary irritation test and skin sensitization test. The SPE did not show any adverse reactions such as erythema and edema on intact skin sites at primary irritation test, but on abraded sites, some experimental animals showed very slight erythema. So, the SPE was classified as a practically non-irritating material based on the score 0.48 of primary irritation index. The skin sensitization study was tested by the guinea pig maximization test (GPMT) and Freund’s complete adjuvant (FCA) with intradermal injection of SPE. The skin sensitization test showed no skin sensitization. Based on this study, the potential for SPE a nutricosmetic and cosmeceutical ingredients were proven.
Key words: Porcine placenta extract, Nutricosmetics, Cosmeceutical, Serum enzyme, Skin safety
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